The biology of the bone regulatory protein sclerostin

Sclerostin is an osteocyte produced protein that negatively regulates osteoblastic bone formation by regulating aspects of both Wnt and BMP signaling. Antibodies to sclerostin have generated exciting preclinical data and are now being assessed in clinic trials for the treatment of  low bone mass disorders such as osteoporosis. The successful candidate will explore the molecular details of sclerostin’s mode of action.

This position requires a PhD in the field of molecular cell biology or protein biochemistry, with innovative scientific accomplishment demonstrated by a solid record of publications.

The applicant is required to have excellent verbal and written communication skills, competence in the English language and a strong motivation to contribute to improving the lives of patients through the creation of breakthrough medicines.

This position is based in Slough, UK. Positions are available for a period of 36 months with a starting date during 2012.

To apply for this position, please visit our Job Seekers' section and search for reference SLO00001669.

If you wish to be considered for this position, you are requested to submit a CV and covering letter detailing:

• Your motivation to undertake the chosen post-doctoral programme and passion for that specific area of science
• A detailed description of your scientific career to date
• Names of two referees
• Date from which you would be available